Optimal Timing for the Administration of Capecitabine with Preoperative Chemoradiation for Locally Advanced Rectal Cancer / Journal of the Korean Cancer Association, 대한암학회지
Cancer Research and Treatment
; : 30-34, 2006.
Article
in En
| WPRIM
| ID: wpr-43443
Responsible library:
WPRO
ABSTRACT
PURPOSE:
Capecitabine is an oral fluoropyrimidine carbamate and it is known as an effective radiosensitizer. Capecitabine and its metabolite reach their peak concentration in the plasma at 1~2 hours after a single oral administration of capecitabine and the levels fall rapidly thereafter. To verify the radiosensitizing effect of capecitabine that is based on such pharmacokinetic characteristics, we performed a retrospective analysis on the optimal timing of capecitabine administration with performing preoperative chemoradiation for locally advanced rectal cancer. MATERIALS ANDMETHODS:
Among 171 patients who were treated with preoperative radiotherapy and concurrent capecitabine administration for rectal cancer, 56 patients were administered capecitabine at 1~2 hours before radiotherapy (group A), and at other time in the other 115 patients (group B). Total mesorectal excision was done at 4 to 6 weeks after the completion of chemoradiation. The radiosensitizing effect of capecitabine was evaluated on the basis of the pathological response.RESULTS:
Complete pathological regression of the primary tumor was observed in 12 patients (21.4%) for group A and in 11 patients (9.6%) for group B (p=0.031). Residual disease less than 0.5 cm (a good response) was observed in 19 patients (33.9%) for group A and in 23 patients (20.0%) for group B (p=0.038). On multivariate analysis, the capecitabine ingestion time showed marginal significance.CONCLUSION:
When performing preoperative chemoradiation for locally advanced rectal cancer, the radiosensitizing effect of capecitabine was enhanced when it was administered 1 hour before radiotherapy.Key words
Full text:
1
Index:
WPRIM
Main subject:
Plasma
/
Radiation-Sensitizing Agents
/
Radiotherapy
/
Rectal Neoplasms
/
Administration, Oral
/
Multivariate Analysis
/
Retrospective Studies
/
Combined Modality Therapy
/
Eating
/
Capecitabine
Type of study:
Observational_studies
Limits:
Humans
Language:
En
Journal:
Cancer Research and Treatment
Year:
2006
Type:
Article