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Association between CyclinA2 gene 5′-UTR polymorphism and genetic susceptibility of colorectal cancer / 重庆医学
Chongqing Medicine ; (36): 64-66, 2014.
Article in Zh | WPRIM | ID: wpr-439851
Responsible library: WPRO
ABSTRACT
Objective To investigate the association between the rs769236 polymorphism at the 5′-UTR region of CyclinA2 gene and the susceptibility of colorectal cancer (CRC) .Methods A case-control study was carried out on the Chinese Han population , the rs769236 polymorphism of CyclinA2 were analyzed by PCR restriction fragment length polymorphism (PCR-RFLP)in 150 CRC cases and 150 healthy controls .The association between CRC risk and the SNP (rs769236) was estimated by an unconditional logis-tic regression model .Results Compared with GG wild genotype ,variant genotypes(GA+AA) carriers had a significantly increased risk of CRC[adjusted odds ratio (OR)=1 .92 ,95% confidence interval(CI)=1 .10 -3 .36] .Conclusion The current results sug-gested that the SNP(rs769236) of CyclinA2 is significantly associated with the increased risk of CRC ,the variant genotypes(GA+AA) are the independent risk factors of CRC in Chinese Han population .
Key words
Full text: 1 Index: WPRIM Type of study: Observational_studies / Prognostic_studies / Risk_factors_studies Language: Zh Journal: Chongqing Medicine Year: 2014 Type: Article
Full text: 1 Index: WPRIM Type of study: Observational_studies / Prognostic_studies / Risk_factors_studies Language: Zh Journal: Chongqing Medicine Year: 2014 Type: Article