IL-6 can upregulate porcine ovarian granulosa cells androgen receptor expression / 基础医学与临床
Basic & Clinical Medicine
; (12): 303-305, 2010.
Article
in Zh
| WPRIM
| ID: wpr-440674
Responsible library:
WPRO
ABSTRACT
Objective To study the effect of intedeukin 6 (IL-6) on the expression of androgen receptor (AR) in porcine ovarian granulosa cells(GC) and to explore its role of in the polycystic ovary syndrome(PCOS) pathogenesis.Methods Different concentrations of IL-6 (10,100 and 1 000 ng/L) were treated with GC.Expression of androgen receptor (AR) mRNA and protein in GC were detected by real-time quantitative RT-PCR and Western blot.Results The mRNA and protein expressions of AR in GC were upregulated in groups with 100 and 1 000 ng/L IL-6 at 72 h.Conclusion IL-6 can improve androgen activity.This process may explain the function of chronic subclinical inflammation in PCOS pathogenesis.
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Index:
WPRIM
Language:
Zh
Journal:
Basic & Clinical Medicine
Year:
2010
Type:
Article