Priming technique can alleviate the withdrawal responses associated with intravenous administration of rocuronium / 대한마취과학회지
Korean Journal of Anesthesiology
; : 628-633, 2009.
Article
in En
| WPRIM
| ID: wpr-44243
Responsible library:
WPRO
ABSTRACT
BACKGROUND:
Intravenous injection of rocuronium is associated with withdrawal responses which are attributable to the pain from the injection of rocuronium. Several methods have been proposed to abolish and attenuate rocuronium-induced pain. We hypothesized priming dose of rocuronium could reduce withdrawal responses associated with administering a second large dose of rocuronium for tracheal intubation. We compared the efficacy of the priming dose technique of rocuronium with intravenous lidocaine as a pre-treatment for the prevention of withdrawal responses associated with rocuronium injection.METHODS:
We recruited 150 patients aged between 18 and 60 years, ASA physical status 1 or 2, who were going to undergo elective surgery requiring general anesthesia. Patients were allocated into three groups. Group C received normal saline, Group L received lidocaine 1 mg/kg, and Group P received rocuronium 0.06 mg/kg 2 minutes before administering a second large dose of rocuronium for tracheal intubation. After the loss of consciousness, rocuronium 0.6 mg/kg was administered intravenously over 10 seconds for tracheal intubation. The withdrawal responses to the injection of rocuronium were evaluated.RESULTS:
The incidence of withdrawal responses associated with rocuronium injection for tracheal intubation was 56, 50, 24% in group C, group L, and group P, respectively. The incidence of withdrawal responses was lower in group P than group C and group L, but there was no difference between group L and group C.CONCLUSIONS:
Priming dose technique is a useful clinical method to alleviate withdrawal responses associated with rocuronium injection.Key words
Full text:
1
Index:
WPRIM
Main subject:
Unconsciousness
/
Incidence
/
Administration, Intravenous
/
Androstanols
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Injections, Intravenous
/
Intubation
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Anesthesia, General
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Lidocaine
Type of study:
Incidence_studies
/
Prognostic_studies
Limits:
Aged
/
Humans
Language:
En
Journal:
Korean Journal of Anesthesiology
Year:
2009
Type:
Article