The Mechanism of Anti-Epileptogenesis by Levetiracetam Treatment is Similar to the Spontaneous Recovery of Idiopathic Generalized Epilepsy during Adolescence
Psychiatry Investigation
;
: 844-850, 2017.
Article
in English
| WPRIM
| ID: wpr-44337
ABSTRACT
OBJECTIVE:
The anti-epileptogenic drug levetiracetam has anticonvulsant and anti-epileptogenesis effects. Synergy between cell death and inflammation can lead to increased levels of apoptosis inhibitory factors and brain-derived neurotrophic factor, aberrant neurogenesis and extended axon sprouting. Once hyperexcitation of the neural network occurs, spontaneous seizures or epileptogenesis develops. This study investigated whether the anti-epileptogenic effect of levetiracetam is due to its alternate apoptotic activity.METHODS:
Adult male Noda epileptic rats were treated with levetiracetam or vehicle control for two weeks. mRNA quantification of Bax, Bcl-2 and GAPDH expression were performed from prefrontal cortex and hippocampus tissue samples.RESULTS:
The levetiracetam-treated group showed a significant increase of Bax/Bcl-2 mRNA expression ratio in the prefrontal cortex than the control group, but no change in the Bax/Bcl-2 mRNA expression ratio in hippocampus.CONCLUSION:
Idiopathic generalized epilepsy including childhood absence epilepsy develop at childhood and recover spontaneously during adolescence. The aberrant neural excitable network is pruned by a neural-maturing action. This study suggests the mechanism of acquired anti-epileptogenesis by levetiracetam treatment may be similar to spontaneous recovery of idiopathic generalized epilepsy during adolescence.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Seizures
/
Axons
/
RNA, Messenger
/
Cell Death
/
Epilepsy, Generalized
/
Epilepsy, Absence
/
Prefrontal Cortex
/
Apoptosis
/
Brain-Derived Neurotrophic Factor
/
Neurogenesis
Limits:
Animals
/
Humans
/
Male
Language:
English
Journal:
Psychiatry Investigation
Year:
2017
Type:
Article
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