Effect of Puerarin on Expression of NF-κB in Rats with Acute Lung Injury Induced by Oleic Acid / 中国药师
China Pharmacist
; (12): 732-734, 2014.
Article
in Zh
| WPRIM
| ID: wpr-446020
Responsible library:
WPRO
ABSTRACT
Objective:
To observe the expression of nuclear factor-kappa B( NF-κB) in rats with acute lung injury ( ALI) caused by oleic acid ( OA) and investigate the protective effect of puerarin ( Pue) in ALI.Methods:
Twenty-four rats were randomly divided into three groupsthe control group, OA group and Pue group. Morphological changes in lung tissues were observed under a light mi-croscope and the expression of NF-κB in lung tissues were examined.Results:
Morphological changes in lung tissues showed that pul-monary inflammation was relieved in Pue group compared with that in OA group. Compared with the control group, the expression of NF-κB was increased obviously in OA group (0. 39 ± 0. 07 vs 0. 12 ± 0. 04, P<0. 05), and that was decreased obviously in Pue group (0. 24 ± 0. 05), which was still higher than that in the control group (P<0. 05).Conclusion:
Puerarin can alleviate the inflammation reaction in ALI through inhibiting the expression of NF-κB.
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WPRIM
Language:
Zh
Journal:
China Pharmacist
Year:
2014
Type:
Article