Observation of the effect of pulmonary surfactant-associated proteins combined with ambroxol in the treat-ment of 180 children with congenital alveolar dysplasia neonatal respiratory distress syndrome / 中国基层医药

ABSTRACT

Objective To observe the effect of pulmonary surfactant-associated proteins ( Kelisu) combined with ambroxol in the treatment of 180 congenital alveolar dysplasia children with neonatal respiratory distress syndrome ( NRDS) .Methods According to random number table ,180 congenital alveolar dysplasia children with NRDS were randomly divided into the observation group and control group , 90 cases in each group .In addition to conventional therapy,the control group was given ambroxol hydrochloride treatment ,the observation group was given Kelisu on thebasis of treatment of the control group.The treatment effect was compared between the two groups .Results Comparedwith the control group,after treatment the values of PaO2 and pH were significantly increased,PaCO2 significantly decreasedin the observation group(t =5.91,13.16,29.89,2.98,5.11,8.13,all P <0.05).The duration of mechanicalventilation,length of hospital stay were (45.30 ±5.35)h,(10.01 ±2.24)d in the observation group,respectively,which were significantly better than[(68.27 ±6.13)h,(17.24 ±2.39)d]in the control group(t =26.78,20.94,all P <0.05).Conclusion Kelisu combined with hydrochloride ambroxol can significantly improve hypoxia symp -toms in NRDS children,reduce the duration of mechanical ventilation and length of hospital stay ,improve the prognosis.