Role of phosphorylation of p53 at Ser392 in cancer therapy / 解剖学报
Acta Anatomica Sinica
; (6): 437-440, 2014.
Article
in Zh
| WPRIM
| ID: wpr-451000
Responsible library:
WPRO
ABSTRACT
Phosphorylation is the most common way of p 53 post-translational modifications .However , gaps still exist in our knowledge regarding the role and mechanism of phosphorylation of p 53 at Ser392 in carcinogenesis and cancer prevention.In the present study, we summarized the effect of phos-p53-Ser392 to wild-type and mutant p53, the regulation by DNA damage agents and protein kinase , and the significance of phosphorylation of p 53-Ser392 in cancer treatment .
Full text:
1
Index:
WPRIM
Language:
Zh
Journal:
Acta Anatomica Sinica
Year:
2014
Type:
Article