4-Aminopyridine (4-AP) augments Ca(2+)-dependent action potential and changes oscillatory firing patterns in rat cerebellar Purkinje cells
Yonsei Medical Journal
; : 112-117, 1999.
Article
in En
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| ID: wpr-45265
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ABSTRACT
Intracellular recordings in cerebellar slice preparation showed that applications of 4-AP altered the pattern of oscillatory firing activity in Purkinje cells (PCs), especially yielding pronounced changes in action potential shape. 4-AP increased the amplitude and duration of action potential significantly and decreased the spike frequency. After 4-AP application, the duration of bursting was prolonged and the duration of after-burst hyperpolarization was progressively shortened. In all PCs tested, the rhythmicity of oscillatory firing activity was abolished completely at the steady state. These results suggest that 4-AP-sensitive currents determine the shape and frequency of individual Ca(2+)-dependent action potentials as well as maintaining oscillatory firing activity in PCs.
Key words
Full text:
1
Index:
WPRIM
Main subject:
Oscillometry
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Purkinje Cells
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In Vitro Techniques
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Action Potentials
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4-Aminopyridine
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Calcium
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Rats, Sprague-Dawley
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Electrophysiology
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Animals
Limits:
Animals
Language:
En
Journal:
Yonsei Medical Journal
Year:
1999
Type:
Article