Effect of perfecting stroke green channel on improving intravenous thrombolysis rate of AIS / 重庆医学

ABSTRACT

Objective To observe the change of door-to-needle time(DNT)and the intravenous thrombolysis rate by recombi-nant tissue plasminogen activator(rt-PA)in the patients with acute ischemic stroke (AIS)after establishing and perfecting the stroke green channel in our hospital.Methods A total of 3 990 patients with AIS in our hospital since 2010 were screened for the statistics on the number of the patients within the time window every year,conducting the analysis on the change trend of the annu-al intravenous thrombolysis rate and DNT.The change situation of DNT and the annual intravenous thrombolysis rate change were compared before the establishment of the stroke green channel and after the establishment and the continuous improvement of the stroke green channel.Results The proportion of AIS patients within the time window in our hospital was significantly lower than that in the domestic developed regions.The intravenous thrombolysis rate by rt-PA achieved the zero breakthrough since the estab-lishment of the stroke green channel in 2011.Along with the continuous improvement of the stroke green channel,the DNT median of the patients within the time window was reduced to 60 min in 2012 and 53.5 min in 2013,moreover the intravenous thrombolysis rate by rt-PA in the patients within the time window was increased from 0 in 2010 to 74.3% in 2013.Conclusion By gradually per-fecting the process of the stroke green channel and strengthening the cooperation of emergency,clinical laboratory and stroke team, DNT is reduced by a large margin and the intravenous thrombolysis rate is substantially increased,which indicates that establishing the perfecting and smooth stroke green channel in the serious pre-hospital delay areas is a necessary measure for increasing the in-travenous thrombolysis rate.