Preparation of Lianzhang Microemulsion / 医药导报

ABSTRACT

Objective To prepare lianzhang microemulsion and investigate its physicochemical properties. Methods The formulation was optimized with the pseudo-ternary phase diagrams drawn in a titration method. The process parameters were screened by a single factor test, and the physical and chemical properties of the microemulsion were preliminarily studied. Results The formulation of lianzhang microemulsion was as follows:copts root extracts:polygonum cuspidatum extractstea oilEL35 propylene glycolwater as 11. 417721. The microemulsion was obtained with mean diameter of 30. 9 nm by stirring the solution for 20 min at 1 400 r·min-1 and 75 ℃. The particles were uniformly distributed,and the microemulsion was clear and transparent without turbidity,phase separation and precipitation after the temperature test and acceleration test. Conclusion The preparation technology of lianzhang microemulsion is simple and stable.