Solubilization of Sulfobutyl Ether-β-cyclodextrin on Voriconazole / 中国药师
China Pharmacist
;
(12): 1457-1460, 2014.
Article
in Chinese
| WPRIM
| ID: wpr-456308
ABSTRACT
Objective:
To research the solubilization of sulfobutyl ether-β-cyclodextrin ( SEB-β-CD) on voriconazole and the sta-bility of voriconazole with different pH values.Methods:
Phase-solubility diagram was applied to study the solubilization of SEB-β-CD on voriconazole. Meanwhile, the impurity of voriconazole was determined to study the stability.Results:
SBE-β-CD could increase the solubility of voriconazole significantly and the apparent stability constant was similar within the pH range of 5. 0-8. 0. The stability of voriconazole was decreased with the increase of pH.Conclusion:
SEB-β-CD is an ideal solubilizer for voriconazole, while the stability is influenced by pH.
Full text:
Available
Index:
WPRIM (Western Pacific)
Language:
Chinese
Journal:
China Pharmacist
Year:
2014
Type:
Article
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