Animal models of spinal cord injury：application and research progress of evoked potentials / 中国组织工程研究

ABSTRACT

BACKGROUND:With the development of industrial society and traffic, the incidence of spinal cord injury has gradualy increased. In addition to radiological laboratory examinations, the neurophysiological test also becomes an effective way of auxiliary examination. Due to the high accuracy and easy operating, neurophysiological test is widely used and the evoked potentials play a role in this project. OBJECTIVE:To summarize the application of somatosensory evoked potentials and motor evoked potentials in rabbits of spinal cord injury. METHODS:A computer-based online research of CNKI and PubMed databases was performed with the key words of “spinal cord injury; evoked potentials; animal models” in Chinese and English. Finaly 33 articles were included in the analysis according to the inclusion and exclusion criteria. RESULTS AND CONCLUSION:The operational approach, waveform analysis, application value, influencing factor of somatosensory evoked potentials and motor evoked potentials were determined in details, the correlation between evoked potentials and prognosis assessment in animals was also detected. Somatosensory evoked potentials is a good indicator for the evaluation of dorsal funiculus of spinal cord, it is easy to operate and reflects the changes of sensory functions. Motor evoked potentials can provide sensitive diagnosis of spinal cord diseases, and they wil be used as a means to assess the spinal cord injury during rehabilitation. The combination of the two can provide a more accurate result.