Optimization of Compatibility Plan for Sodium Nitroprusside and Infusions by Orthogonal Design / 中国药师
China Pharmacist
;
(12): 1960-1962, 2014.
Article
in Chinese
| WPRIM
| ID: wpr-460017
ABSTRACT
Objective:
To investigate the best compatibility plan for nitroprusside sodium for injection.Methods:
An L16 (43 × 26 ) orthogonal design was used with four factorstemperature, solvent, solvent volume and time. The content of sodium nitroprusside was detected by HPLC, the insoluble particles were observed by a GWF-5J type particle analyzer, pH was detected by a PHS-2C preci-sion acidity meter, and a comprehensive scoring method was used to optimize the compatibility plan.Results:
The optimized compati-bility plan was as follows50mg sodium nitroprusside was dissolved in 250ml sodium chloride injections, avoiding light and used up in 26h.Conclusion:
The plan provides scientific basis for the clinical medication.
Full text:
Available
Index:
WPRIM (Western Pacific)
Language:
Chinese
Journal:
China Pharmacist
Year:
2014
Type:
Article
Similar
MEDLINE
...
LILACS
LIS