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Determination of Entrapment Efficiency of Loratadine Binary Ethosomes by Sephadex Microcolumn Com-bined with HPLC / 中国药师
China Pharmacist ; (12): 244-246, 2015.
Article in Chinese | WPRIM | ID: wpr-461129
ABSTRACT

Objective:

To establish a method to determine the entrapment efficiency of loratadine binary ethosomes.

Methods:

The gel microcolumn centrifugation method was employed to separate the free drug from loratadine binary ethosomes. The content of lorata-dine was determined by HPLC to calculate the entrapment efficiency.

Results:

A calibration linear curve of loratadine concentration was within the range of 10. 2-102. 0 μg·ml-1(r=0. 999 5). The average entrapment efficiencies of three batches of loratadine binary ethosomes were 86. 75%, 87. 26% and 86. 00%, respectively.

Conclusion:

The method is simple and rapid, and can be used to de-termine the entrapment efficiency of loratadine binary ethosomes accurately.

Full text: Available Index: WPRIM (Western Pacific) Language: Chinese Journal: China Pharmacist Year: 2015 Type: Article

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Full text: Available Index: WPRIM (Western Pacific) Language: Chinese Journal: China Pharmacist Year: 2015 Type: Article