Determination of Entrapment Efficiency of Loratadine Binary Ethosomes by Sephadex Microcolumn Com-bined with HPLC / 中国药师
China Pharmacist
;
(12): 244-246, 2015.
Article
in Chinese
| WPRIM
| ID: wpr-461129
ABSTRACT
Objective:
To establish a method to determine the entrapment efficiency of loratadine binary ethosomes.Methods:
The gel microcolumn centrifugation method was employed to separate the free drug from loratadine binary ethosomes. The content of lorata-dine was determined by HPLC to calculate the entrapment efficiency.Results:
A calibration linear curve of loratadine concentration was within the range of 10. 2-102. 0 μg·ml-1(r=0. 999 5). The average entrapment efficiencies of three batches of loratadine binary ethosomes were 86. 75%, 87. 26% and 86. 00%, respectively.Conclusion:
The method is simple and rapid, and can be used to de-termine the entrapment efficiency of loratadine binary ethosomes accurately.
Full text:
Available
Index:
WPRIM (Western Pacific)
Language:
Chinese
Journal:
China Pharmacist
Year:
2015
Type:
Article
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