Effect of angiotensinⅡon expression of Notch pathway and Nephrin in podocyte / 中国药理学通报
Chinese Pharmacological Bulletin
; (12): 247-250, 2015.
Article
in Zh
| WPRIM
| ID: wpr-462597
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WPRO
ABSTRACT
Aim To investigate the expression of Notch pathway and Nephrin in angiotensin Ⅱ ( AngⅡ)-stimulated mice podocyte. Methods Mice podo-cyte was stimulated by AngⅡ, and then was treated with valsartan. The levels of Notch1, Notch intracellu-lar domain 1 ( NICD1 ) , Hes1 and Nephrin were deter-mined by immunofluorescence, Western blot and Real-time PCR. Results AngⅡincreased Notch1, NICD1 and Hes1 expression, and decreased Nephrin expres-sion in a time-dependent manner ( P<0. 01 ) . Valsar-tan inhibited AngⅡ-induced activation of Notch path-way and enhanced Nephrin level ( P <0. 01 ) . Con-clusion AngⅡdecreases Nephrin expression in podo-cyte by activating Notch pathway.
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Language:
Zh
Journal:
Chinese Pharmacological Bulletin
Year:
2015
Type:
Article