The expression of FGF-5 and FGF-7 in the cyclosporin a-induced gingival hyperplasia
Journal of the Korean Association of Oral and Maxillofacial Surgeons
; : 216-221, 2006.
Article
in Ko
| WPRIM
| ID: wpr-46440
Responsible library:
WPRO
ABSTRACT
Cyclosporin A-induced gingival hyperplasia is frequently found in the patients who have been received an immunosuppressant for the organ transplantation. However, its exact mechanism is still unknown. The expression of FGF-5 and FGF-7 were studied in cyclosporine A-induced gingival hyperplasia (CGH) and inflammatory gingival hyperplasia (IGH). Immunohistochemistry and in situ hybridization were used for localization of protein and mRNA. The expression of FGF-5 and FGF-7 was different from CGH and IGH. FGF-5 and FGF-7 was strongly expressed in fibroblast in CGH (P<0.005 and P<0.05, respectively). FGF-5 mRNA was localized in the middle portion of connective tissue. FGF-7 mRNA was also identified in fibroblasts and mast cells. In conclusion, FGF-5 and FGF-7 were produced excessively by fibroblasts in CGH. Considering their known functions, their expression in CGH is important for production of collagen and proliferation of fibroblasts.
Key words
Full text:
1
Index:
WPRIM
Main subject:
RNA, Messenger
/
Immunohistochemistry
/
Organ Transplantation
/
Collagen
/
Cyclosporine
/
In Situ Hybridization
/
Connective Tissue
/
Transplants
/
Fibroblasts
/
Gingival Hyperplasia
Limits:
Humans
Language:
Ko
Journal:
Journal of the Korean Association of Oral and Maxillofacial Surgeons
Year:
2006
Type:
Article