Brain Tumor Stem Cells as Therapeutic Targets in Models of Glioma
Yonsei Medical Journal
; : 633-640, 2010.
Article
in En
| WPRIM
| ID: wpr-46868
Responsible library:
WPRO
ABSTRACT
At this time, brain tumor stem cells remain a controversial hypothesis while malignant brain tumors continue to present a dire prognosis of severe morbidity and mortality. Yet, brain tumor stem cells may represent an essential cellular target for glioma therapy as they are postulated to be the tumorigenic cells responsible for recurrence. Targeting oncogenic pathways that are essential to the survival and growth of brain tumor stem cells represents a promising area for developing therapeutics. However, due to the multiple oncogenic pathways involved in glioma, it is necessary to determine which pathways are the essential targets for therapy. Furthermore, research still needs to comprehend the morphogenic processes of cell populations involved in tumor formation. Here, we review research and discuss perspectives on models of glioma in order to delineate the current issues in defining brain tumor stem cells as therapeutic targets in models of glioma.
Key words
Full text:
1
Index:
WPRIM
Main subject:
Neoplastic Stem Cells
/
Brain Neoplasms
/
Signal Transduction
/
Receptors, Notch
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Phosphatidylinositol 3-Kinase
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Glioma
Limits:
Animals
/
Humans
Language:
En
Journal:
Yonsei Medical Journal
Year:
2010
Type:
Article