New synthesis method of chlorpropamid

ABSTRACT

The chlorpropamid (1) is an antidiabetic drug synthetized from chlorobenzene (2) in five steps through intermediates p-clorobenzenesulfonyl chloride (3), calcium p-chlorobenzene sulfonyl cyanamide (6), p-clorobenzenesulfonyl cyanamide (7), p-clorobenzenesulfonyl urea (8) and then the compound 8 was condensated with n-propylamine. The product have melting point, Rf, IR spectral data that suitable with to the chlopropamid extracted from Novopropamid tablet of Canada.