The Role of CXCR7 on Proliferation, Adhesion and Invasion of Gastric Cancer / 天津医药

ABSTRACT

Objective To investigate the expression of CXCR7 in gastric carcinoma tissues and the role of CXCR7 in tumor growth, adhesion and invasion of gastric cancer. Methods The expression levels of CXCR7, Survivin, CD44v6 and matrix metalloproteinase (MMP)-3 were detected by immunnohistochemistry method in gastric cancer specimens came from 160 patients (gastric cancer group) and 30 specimens of normal gastric tissues (control group). Results The expression of CXCR7 protein was significantly higher in gastric cancer group than that of control group (P<0.05). The positive CXCR7 staining was significantly different with tumor size, depth of invasion, lymph node metastasis and clinical staging ( P<0.05). CXCR7 expression was positively correlated with Survivin, CD44v6 and MMP-3. Conclusion CXCR7 might take part in progression of gastric cancer by anti-apoptosis (Survivin). CXCR7 might take part in the lymph node metastasis of gastric cancer and mediate the adhesion and invasion by CD44v6 and MMP-3.