Effect of Pomegranate Tannins on Endogenous Metabolites in Rat Urine / 中国药师
China Pharmacist
; (12): 1609-1612, 2014.
Article
in Zh
| WPRIM
| ID: wpr-475791
Responsible library:
WPRO
ABSTRACT
Objective:To study the influence of pomegranate tannins on the endogenous metabolites in the urine of normal rats by metabonomics method. Methods:The rats were divided into two groups, the blank control group and tannins group. The rats in tan-nins group were orally administered 78. 5 mg·ml-1 pomegranate tannins for 4 weeks. The urine samples were collected and used in the metabonomics study. The urine data were collected by HPLC-MS and comparatively analyzed using PCA and PLS-DA method in SIM-CA-P software. Results:The score points of tannins group displayed obvious distance compared with those of the blank control group, and the changes were the most obvious on the 22nd administration day. Conclusion:Endogenous metabolites in rat urine are obviously influenced by pomegranate tannins, and the research provides the basis for the further study of pomegranate tannins.
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WPRIM
Language:
Zh
Journal:
China Pharmacist
Year:
2014
Type:
Article