Relationship of different histological classifications of gastric cancer with microvessel density and related factors / 中国肿瘤临床
Chinese Journal of Clinical Oncology
; (24): 737-742, 2015.
Article
in Zh
| WPRIM
| ID: wpr-476804
Responsible library:
WPRO
ABSTRACT
Objective:
To investigate the correlations of Lauren classification and world health organization (WHO) classification of gastric cancer (GC) with microvascular density (MVD), matrix metalloproteinase-2 (MMP-2), matrix metalloproteinase-9 (MMP-9), vascular endothelial growth factor (VEGF), vascular endothelial growth factor receptor 1 (VEGFR1), vascular endothelial growth factor receptor 2 (VEGFR2), and p53.Methods:
The clinical data of 89 patients with GC were collected. The collected specimens were categorized on the basis of Lauren classification and WHO classification. CD34/periodic acid-Schiff (PAS) double staining was performed to validate MVD. Immunohistochemistry was conducted to investigate the expression levels of MMP-2, MMP-9, VEGF, VEGFR1, VEGFR2, and p53.Results:
MVD was not correlated with Lauren classification or WHO classification (P>0.05). Lauren typing was associated with the expression levels of MMP-9, VEGFR1, and p53 (P0.05). Cox proportional hazards model revealed that Lauren classification and WHO classification were the prognostic factors of overall survival (P<0.05).Conclusion:
This research on tumor related factors, angiogenesis, and different classifications of GC may provide new methods to treat this disease.
Full text:
1
Index:
WPRIM
Type of study:
Prognostic_studies
Language:
Zh
Journal:
Chinese Journal of Clinical Oncology
Year:
2015
Type:
Article