Correlation between long non-coding RNA in tumor tissues and clinico-pathological characteristics of hepatocellular carcinoma / 中华肝胆外科杂志
Chinese Journal of Hepatobiliary Surgery
; (12): 604-607, 2015.
Article
in Zh
| WPRIM
| ID: wpr-477369
Responsible library:
WPRO
ABSTRACT
Objective To evaluate the relationship between long non-coding RNAs (LncRNA) in tumor tissues and clinico-pathological features of hepatocllular carcinoma (HCC).Methods Using hepatocellular carcinoma gene database GSE36376,we conducted a study on eight LncRNAs which are associated with liver diseases and analyzed the correlation between these LncRNAs and HCC clinico-pathological characteristics.We also evaluated the potential effect of LncRNAs on HCC development.Results H19 was overexpressed in non-tumorous tissues of HCC (P < 0.05),while MEG3,HOXA13,KCNQ1OT1 were all upregulated in tumorous tissues (all P < 0.05).HULC level in HCC tumorous tissues was negatively correlated with AJCC staging,BCLC staging and tumor size (all P < 0.05).UCA1 was positively correlated with BCLC staging (r =0.135,P < 0.05).Univariate analysis and multivariate logistic analyses showed that UCA1 was a risk factor of intrahepatic metastasis of HCC (OR =6.054,95% CI =1.429 ~ 25.642,P < 0.05); in contrast,HULC overexpression in tumorous tissues played a positive role in HCC tumor size (OR=0.805,95%CI=0.678 ~0.956,P<0.05).Conclusion HULC in tumorous tissues suppressed HCC proliferation,while UCA1 was a risk factor of HCC aggressiveness.
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Index:
WPRIM
Language:
Zh
Journal:
Chinese Journal of Hepatobiliary Surgery
Year:
2015
Type:
Article