MicroRNAs regulates the high density lipoprotein biogenesis and its transport / 中华检验医学杂志
Chinese Journal of Laboratory Medicine
;
(12): 436-438, 2015.
Article
in Chinese
| WPRIM
| ID: wpr-478445
ABSTRACT
High density lipoprotein ( HDL ) has been considered as an important mediator in favoring cardioprotective effects .However , recent studies revealed that HDL-C-raising therapeutics alone failed to reduce the risk of cardiovascular diseases , suggesting that the HDLfunctionalitymay be more critical for its cardioprotective properties than the simple HDL-C levels.microRNAs ( miRNAs) have been identified as the novel regulators of lipid metabolism and played essential roles in the key steps of reverse cholesterol transport, involving in HDL biogenesis , cellular cholesterol mobilization , hepatic HDL uptake and excretion.The intensive research on lipid metabolism-related miRNAs may provide further clarification on the molecular regulatory mechanisms for HDL-mediated reverse cholesterol transport and plasma HDL-C levels, advancing our knowledge on the effects of HDL in pathogenesis and progression of cardiovascular diseases.
Full text:
Available
Index:
WPRIM (Western Pacific)
Language:
Chinese
Journal:
Chinese Journal of Laboratory Medicine
Year:
2015
Type:
Article
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