A meta-analysis of stroke risk in type 2 diabetic patients treated with sulfonylurea / 中华内分泌代谢杂志
Chinese Journal of Endocrinology and Metabolism
;
(12): 758-764, 2015.
Article
in Chinese
| WPRIM
| ID: wpr-478754
ABSTRACT
Objective To investigate whether sulfonylurea ( SU) increases the risk of stroke in patients with type 2 diabetes mellitus(T2DM). Methods A systemic meta-analysis including 17 random control trails(RCT) was performed to compare the risk of stroke between type 2 diabetic patients treated with SUs and comparators. Results 1 612 articles were retrieved, and finally 17 articles were included. Patients receiving SUs treatment had a higher relative risk of stroke (RR 1. 35, 95% CI 1. 13-1. 60) than those who received comparators. The I2 statistic for heterogeneity between 17 trails was 0. 0%(P=0. 687). No major asymmetry appeared in the funnel plot and Begg′adjusted rank correlation test(kendall′s score=22, P=0. 387). Conclusion The use of SUs may raise the risk of stroke which is already high in patients with T2DM.
Full text:
Available
Index:
WPRIM (Western Pacific)
Type of study:
Etiology study
/
Systematic reviews
Language:
Chinese
Journal:
Chinese Journal of Endocrinology and Metabolism
Year:
2015
Type:
Article
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