Clinical application of zinc finger protein A20 / 肿瘤研究与临床
Cancer Research and Clinic
; (6): 791-792, 2015.
Article
in Zh
| WPRIM
| ID: wpr-485275
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ABSTRACT
Pathologist Dixit in American Michigan University found a gene induced by cytokine from human umbilical vein endothelial cells in 1990.This gene is increased in a variety of cells rapidly and coded a special kind of the zinc finger protein when being stimulated by interleukin-1 (IL-1),PLS and tumor necrosis factor (TNF).The gene was named as zinc finger protein A20 gene,and its coding protein was named as zinc finger protein A20.A20 is a kind of endogenous regulatory protein,inhibiting the inflammatory reaction and cell apoptosis through the inhibition of NF-kappa B activity.This article mainly reviewed the structure,function and clinical significance of A20.
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Language:
Zh
Journal:
Cancer Research and Clinic
Year:
2015
Type:
Article