Retrospectively analyzed the result of HCMV-DNA of breast milk and urine of neonatal hyperbilirubinemia in 461 cases / 国际检验医学杂志

ABSTRACT

Objective To retrospectively analyze the result of HCMV‐DNA of breast milk and urine of neonatal hyperbilirubi‐nemia and evaluate the effect on screening neonatal hyperbilirubinemia .Methods Collected 461 cases of neonatal hyperbilirubinemia from January 2014 to December 2014 in our hospital ,which fed with breast milk as observation group ,at the same period collected 450 cases of healthy newborn in our hospital as control group .Tested the their level of HCMV‐DNA in breast milk and urine with Fluorescent Quantitative PCR ,recorded the testing results .Results 239 cases with positive HCMV‐DNA urine were detected in observation group ,accounting for 51 .8% .There were 89 cases of positive HCMV‐DNA urine in control group ,which accounted for 19 .8% ,the comparative difference was statistically significant(P< 0 .01) .There were 367 cases of positive HCMV‐DNA breast milk in observation group ,accounting for 79 .6% .The positive HCMV‐DNA breast milk were detected in 137 cases in control group ,which accounted for 30 .4% ,the comparative difference was statistically significant (P<0 .01) .Conclusion The breast milk of HCMV infection was an important way of neonatal HCMV infection ,the HCMV‐DNA detection of breast milk and urine was of great significance to the diagnosis of neonatal hyperbilirubinemia .