Prevalence and antibiotic resistance proifle ofHelicobacter pylori in Shanghai / 中国感染与化疗杂志
Chinese Journal of Infection and Chemotherapy
; (6): 346-352, 2016.
Article
in Zh
| WPRIM
| ID: wpr-493484
Responsible library:
WPRO
ABSTRACT
Objective To examine the prevalence ofHelicobacter pylori in Shanghai and relevant risk factors, evaluate the resistance proifle ofH. pylori isolates to antibiotics used in ifrst-line therapy in two hospitals in Shanghai.MethodsH. pylori were isolated from the biopsy samples of gastric mucosa collected from September 2013 to January 2015. Antimicrobial susceptibility test was performed by E-test method for 131H. pylori strains to 4 antibiotics, clarithromycin, metronidazole, amoxicillin and tetracycline. Results A total of 955 patients receiving gastroscopy were enrolled. And 248 (26.0%)H. pylori strains were isolated from the biopsy samples of gastric mucosa. Overall, 14.5%, 64.1%, 0 and 0.8% of the strains were resistant to clarithromycin, metronidazole, amoxicillin and tetracycline, respectively. Resistance to two drugs was found in 10.7%(14/131) of the strains, and majority (92.8%, 13/14) of which were resistant to clarithromycin and metronidazole.Conclusions The prevalence ofH. pylori in gastric mucosa is rather lower compared with the data reported previously. It is associated with the sex, age and clinical outcome of patients, however, antibiotic resistance profile is not related to these factors.H. pylori eradication therapy should be individualized according to the results of susceptibility test in Shanghai.
Full text:
1
Index:
WPRIM
Type of study:
Prevalence_studies
/
Risk_factors_studies
Language:
Zh
Journal:
Chinese Journal of Infection and Chemotherapy
Year:
2016
Type:
Article