Progression of Bruton tyrosine kinase (BTK) inhibitor in B-cell lymphoma / 中国肿瘤临床
Chinese Journal of Clinical Oncology
;
(24): 598-602, 2016.
Article
in Chinese
| WPRIM
| ID: wpr-495365
ABSTRACT
Chronic activation of the B-cell antigen receptor (BCR) signaling pathway performs a critical function in the pathogenesis of numerous subtypes of B-cell malignancies and transforms normal cells into malignant cells. Bruton tyrosine kinase (BTK) is a member of the TEC family of tyrosine kinases and is a key regulator of the BCR signaling pathway. BTK inhibition has emerged as a new target for therapeutic intervention in B-cell malignancies. This review summarizes recent developments of BTK inhibitors in B-cell malignan-cies.
Full text:
Available
Index:
WPRIM (Western Pacific)
Language:
Chinese
Journal:
Chinese Journal of Clinical Oncology
Year:
2016
Type:
Article
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