Expression and clinical significance of clusterin in acute cerebral infarction / 重庆医学

ABSTRACT

Objective To investigate the expression and clinical significance of clusterin (CLU ) in acute cerebral infarction (ACI) .Methods A total of 154 inpatients with ACI within 48 h of the first onset in the First Affiliated Hospital of Nanchang Uni‐versity from May to December 2013 served as the ACI group and divided into subgroups according to the neural function defection degree and whether having plaque .Contemporaneous 45 individuals undergoing the healthy physical examination were selected as the control group .The serum CLU and complement C3 levels were detected .The National Institutes of Health Stroke Scale (NIH‐SS) and Barthel index scores were conducted ,the rehabilitation course and outcome until 90 d after onset were followed up ,and the comparative analysis on serum CLU level was performed .Results The serum CLU and complement C3 levels in the ACI group were significantly higher than those in the control group ,the differences were statistically significant (P0 .05) ,the serum CLU level had statistically significant differences among other prognosis types of the patients groups (P<0 .01 or P<0 .05) .The lower the serum CLU level ,the rehabilitation the better .Conclusion CLU play a role by regulating the complement system after cerebral infarction occurrence ,serum CLU level is correlated with carotid arterial plaque ,neurological function defection degree and prognosis in ACI patients ,which can serve as one of biochemical indicators for evaluating the disease condition and guiding prognosis in ACI patients .