Reviews on association between the inhibitory costimulatory molecules B7 -H4 and female malignant tumor / 实用肿瘤学杂志
Practical Oncology Journal
; (6): 53-56, 2015.
Article
in Zh
| WPRIM
| ID: wpr-499250
Responsible library:
WPRO
ABSTRACT
The new costimulatory molecule B7-H4,also called V-set domain containing T cell activa-tion inhibitor 1(VTCN-1),is a member of the B7 family.B7-H4 can negatively regulate the immune response of T lymphocytes through inhibiting their proliferation and cytokine production .The expression of B7-H4 plays an important role in initiation ,progression and regression of malignant tumors ,including female malignant tumor , such as breast cancer ,ovarian cancer and uterine neoplasm .The association between the female tumors and B 7-H4 causes great concern in recent years .In this review,the function of B7-H4 in female tumor research and the potential target of B7-H4 in the diagnosis and treatment of female tumor are summarized .
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Index:
WPRIM
Language:
Zh
Journal:
Practical Oncology Journal
Year:
2015
Type:
Article