Treatment outcome in patients with vulvar cancer: comparison of concurrent radiotherapy to postoperative radiotherapy
Radiation Oncology Journal
; : 20-26, 2012.
Article
in En
| WPRIM
| ID: wpr-49998
Responsible library:
WPRO
ABSTRACT
PURPOSE:
To evaluate outcome and morbidity in patients with vulvar cancer treated with radiotherapy, concurrent chemoradiotherapy or postoperative radiotherapy. MATERIALS ANDMETHODS:
The records of 24 patients treated with radiotherapy for vulvar cancer between July 1993 and September 2009 were retrospectively reviewed. All patients received once daily 1.8-4 Gy fractions external beam radiotherapy to median 51.2 Gy (range, 19.8 to 81.6 Gy) on pelvis and inguinal nodes. Seven patients were treated with primary concurrent chemoradiotherapy, one patient was treated with primary radiotherapy alone, four patients received palliative radiotherapy, and twelve patients were treated with postoperative radiotherapy.RESULTS:
Twenty patients were eligible for response evaluation. Response rate was 55% (11/20). The 5-year disease free survival was 42.2% and 5-year overall survival was 46.2%, respectively. Fifty percent (12/24) experienced with acute skin complications of grade III or more during radiotherapy. Late complications were found in 8 patients. 50% (6/12) of patients treated with lymph node dissection experienced severe late complications. One patient died of sepsis from lymphedema. However, only 16.6% (2/12) of patients treated with primary radiotherapy developed late complications.CONCLUSION:
Outcome of patients with vulvar cancer treated with radiotherapy showed relatively good local control and low recurrence. Severe late toxicities remained higher in patients treated with both node dissection and radiotherapy.Key words
Full text:
1
Index:
WPRIM
Main subject:
Pelvis
/
Recurrence
/
Skin
/
Vulvar Neoplasms
/
Carcinoma, Squamous Cell
/
Retrospective Studies
/
Treatment Outcome
/
Sepsis
/
Disease-Free Survival
/
Chemoradiotherapy
Type of study:
Observational_studies
Limits:
Humans
Language:
En
Journal:
Radiation Oncology Journal
Year:
2012
Type:
Article