Fibrillary glomerulonephritis combined with chronic inflammatory demyelinating polyneuropathy
Kidney Research and Clinical Practice
; : 117-119, 2015.
Article
in En
| WPRIM
| ID: wpr-50605
Responsible library:
WPRO
ABSTRACT
A 58-yr-old man presented with leg edema and subacute weakness of his bilateral lower extremities. Urinary and serum immunoelectrophoresis revealed the presence of lambda-type Bence Jones proteins. He was ultimately diagnosed with monoclonal gammopathy of undetermined significance (MGUS). A renal biopsy specimen showed fibrillary glomerulonephritis (FGN), which was randomly arranged as 12-20 m nonbranching fibrils in the basement membranes. Immunofluorescence studies were negative for immunoglobulin (Ig)G, IgM, IgA, C3, and kappa light chains in the capillary walls and mesangial areas. A Congo red stain for amyloid was negative. Electromyography and nerve conduction velocity examinations results were compatible with the presence of demyelinating polyneuropathy. This case showed a rare combination of FGN, without Ig deposition, and MGUS combined with chronic inflammatory demyelinating polyneuropathy (CIDP).
Key words
Full text:
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Index:
WPRIM
Main subject:
Paraproteinemias
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Polyneuropathies
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Basement Membrane
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Biopsy
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Monoclonal Gammopathy of Undetermined Significance
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Bence Jones Protein
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Immunoglobulin A
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Immunoglobulin M
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Immunoglobulins
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Capillaries
Language:
En
Journal:
Kidney Research and Clinical Practice
Year:
2015
Type:
Article