Efficacy and Pharmacoeconomic Analysis of Four Proton-pump Inhibitors in the Treatment of Duodenal Ulcer with Hemorrhage / 中国药师

ABSTRACT

Objective:To evaluate the therapeutic effects and pharmacoeconomic results of four proton-pump inhibitors in the duo-denal ulcer patients with hemorrhage. Methods:Using a retrospective analysis, 90 duodenal ulcer patients with hemorrhage were in-volved. According to the proton pump inhibitors, there was no statistic difference among those groups(P>0. 05). The mean time to stop bleading,hemostalsis rate,and the incidance of adverse drug reactions of those four groups,there were no statistic differece too( P>0. 05). The cost of pantprazole group was much lower than the other three groups by cost-minimication analysis. Results:The effective rate of the four groups was 80. 0%, 86. 7%, 90. 0% and 90. 0%, respectively;there was no statistic difference among those groups(P>0. 05). The mean time to stop bleeding, hemostasis rate, and the incidence of adverse drug reactions of those four groups, there were no statistic difference too(P>0. 05). The cost of pantoprazole group was much lower than the other three groups by cost-minimization alanysis. Conclusion:The effect and safety of the four groups were basically equivalent, while the coot of pantoprazole is lowest, it is the best treatment plan by pharmacoeceonomics.