Preparation of Vitamin B1 Sustained-release Tablets / 中国药师
China Pharmacist
; (12): 453-457, 2017.
Article
in Zh
| WPRIM
| ID: wpr-510008
Responsible library:
WPRO
ABSTRACT
Objective:
To screen the optimal formula and preparation process of vitamin B1 ( VB1 ) sustained-release tablets.Methods:
The single-factor tests were used to investigate the type of filler, type and amount of matrix material hydroxypropyl methycel-lulose(HPMC), type and amount of retarder, tablet weight and core hardness. The orthogonal tests were used to investigate the amount of HPMC and ethyl cellulose( EC) and the core hardness.Results:
The optimum formula was as followsHPMC accounted for 50% of the tablet weight, EC accounted for 20%, the filler was lactose, the tablet weight was 200 mg and the tablet core hardness was 50 N.Conclusion:
The prepared sustained-release tablets have significant controlled-release property, which provides reference for the devel-opment of new dosage form for VB1 .
Full text:
1
Index:
WPRIM
Language:
Zh
Journal:
China Pharmacist
Year:
2017
Type:
Article