The clinical efficacy of different adding times, treatment courses and doses of probiotics for Helicobacter pylori eradication / 实用医学杂志
The Journal of Practical Medicine
; (24): 395-398, 2017.
Article
in Zh
| WPRIM
| ID: wpr-511575
Responsible library:
WPRO
ABSTRACT
Objective To investigate the efficacy of different adding times,treatment courses and doses of bifidobacterium and lactobacillus triple live bacteria in Helicobacter pylori (Hp) eradication.Methods A total of 280 patients Hp-infected were enrolled and randomly assigned to five groups.Group A received lansoprazole 30 mg,clarithromycin 500 mg and amoxicillin 1,000 mg bid for 14 days;group B received bifidobacterium and lactobacillus triple live bacteria 2,000 mg tid for 14 days followed by regimen of group A for another 14 days;group C1 received regimen of group A with addition of bifidobacterium and lactobacillus triple live bacteria 2,000 mg bid for 14 days;group C2:regimen of group A with addition of bifidobacterium and lactobacillus triple livc bacteria 2,000 mg tid for 14 days;and group D received regimen of group C2 followed by bifidobacterium and lactobacillus triple live bacteria 2,000 mg tid for another 14 days.4 weeks after end of treatment,Hp eradication was assessed by 13C-urea breath test.Adverse effects during the courses of treatment were recorded.Results A total of 252 (90.0%) patients completed the treatment.The completion rate in group A,B,C1,C2,and D were 78.6% (44/56),92.9% (52/56),87.5% (49/56),96.4% (54/56),and 94.6% (53/56) respectively;the completion rate was significantly higher in group B,C2 and D than in group A (P < 0.05),but there were no differences among groups B,C2 and D (P > 0.05).According to intention-to-trcat (ITT) analysis,the eradication rate was 62.5%,80.4%,69.6%,85.7%,and 87.5% in groups A,B,C1,C2,and D respectively.The eradication rate in groups B,C2 and D was significantly higher than that in group A (x2 =4.375,P =0.036;x2 =7.864,P =0.005;x2 =9.333,P =0.002),and the eradication rate was higher in group C2 than in group C1 (x2 =4.171,P =0.041),but there were no differences among groups B,C2 and D (P >0.05).As for per-protocol (PP) analysis,the eradication rate was 79.5%,86.5%,79.6%,88.9% and 92.5% in groups A,B,C1,C2,and D respectively,but no significant statistical differences were found among the five groups (P > 0.05).Adverse effects included nausea,bloating,taste distortion,anorexia and constipation.The rate of adverse effects in groups A,B,C1,C2 and D was 67.9% (38/56),26.8% (15/56),35.7% (20/56),21.4% (12/56),and 17.9% (10/56) respectively.The incidence rate was significantly lower in groups B,C2 and D than in group A (P < 0.05),but no significant statistical differences were found among groups B,C2,and D (P > 0.05).Conclusions The triple therapy combined with bifidobacterium and lactobacillus triple live bacteria can obviously decrease the adverse effects and improve patient compliance,thereby increasing the rate of Hp eradication.14-day therapy with probiotics is the best regimen.
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Index:
WPRIM
Type of study:
Guideline
Language:
Zh
Journal:
The Journal of Practical Medicine
Year:
2017
Type:
Article