Comparative Study on HPV Infection and Hypotype Distribution between Ankang and Yan'an Area of Shaanxi Province / 现代检验医学杂志

ABSTRACT

Objective Compare the HPV infection characters between women in different geographic area of Ankang (south of Shaanxi) and Yanan (north of Shaanxi),to provide evidence based reference for cervical cancer control.Methods PCR amplification in vitro combined reverse dot-blot hybridization assay were used to analyze HPV genotypes of 7 912 cases from Ankang City Center Hospital,and 3 543 cases from Yanan Affiliated Hospital of Yanan Medical University from June 2012 to July 2016,and compared HPV infection rate,age and hypotype distribution of the cases.Results The HPV infection rate of Ankang area was 21.75％ (1 721/7 912),and Yanan area was 41.41％ (1 402/1 721).The percentage of HPV positive women with high-risk hypotype was 81.46％ (1 402 1 721) in Ankang and 86.16％ (1 264/1 467) in Yanan,with low-risk hypotype was 11.04％ (190/1 721) in Ankang and 7.23％ (106/1 467) in Yanan,with high and low risk hypotype was 7.50％ (129 147) in Ankang and 6.61％ (97/1 467) in Yanan.The women more than 60 year old were higher HPV prevalence age group.The HPV infection rate of this age group was 30.41％ (104/342) in Ankang,and 50.00 ％ (60/120) in Yanan.Yanan's HPV infection rate was obviously higher than Ankang.The popular HPV hypotypes in Yanan were same with that in Ankang.The most popular high-risk hypotypes were HPV16,58 and 52,the most popular low-risk hypotypes were 6,11 and 81.Conclusion The HPV infection rate were rather high in all age group.The most popular HPV hypotypes were same between Ankang and Yanan area.But Yanan's HPV infection rate was obviously higher than Ankang (P＜ 0.01).The causes need further explore.