Pathological evaluation of immune system in drug safety study / 药物评价研究
Drug Evaluation Research
; (6): 1-4, 2017.
Article
in Zh
| WPRIM
| ID: wpr-515092
Responsible library:
WPRO
ABSTRACT
The immune system is a complex system involving multiple organs,and it is vulnerable to age,gender,environment and other factors.For a variation normal physiological range,it is a great challenge to evaluate drug-induced immunotoxicity in preclinical safety study.Histomorphologic assessment of the immune system is a recognized cornerstone in the identification of immunotoxicity at present.In this paper,the principles of pathological evaluation for immune system,and pathological evaluation for important immune organs including thymus,spleen,lymph nodes are discussed briefly,so that it is intended to assist toxicity pathologists in the accurate and consistent characterization of intended and unintended drug-induced alterations of the immune system.
Full text:
1
Index:
WPRIM
Language:
Zh
Journal:
Drug Evaluation Research
Year:
2017
Type:
Article