Effects of ketamine on nitric oxide/cyclic guanosine 3',5'-monophosphate signaling pathway in the rat brain in vivo / 中华麻醉学杂志
Chinese Journal of Anesthesiology
; (12)1994.
Article
in Zh
| WPRIM
| ID: wpr-516649
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WPRO
ABSTRACT
To investigate the effects of ketamine on nitric oxide synathase(NOS)activity, nitrc oxide (NO) output and cyclic guanosine 3', 5'-monophosphate(cGMP)content in the rat brain. Method: Thirty two SD rats were divided randomly into control group and ketamine group. The aminals were administred intraperitoneally(ip)normal saline 10mg?kg~(-1) or ketamine 100mg?kg~(-1), respectively. NOS activity and NO output were assassed with spectrophotometric analysis, cGMP content was measured with radioimmunoassay, Result: Ketamine 100mg?kg~(-1) ip significantly inhibited NOS activity(P
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Index:
WPRIM
Language:
Zh
Journal:
Chinese Journal of Anesthesiology
Year:
1994
Type:
Article