Study on the Influence of Arsenic Trioxide on the Expressions of Gastric Cancer Cell Metastasis Associated Genes

Study on the Influence of Arsenic Trioxide on the Expressions of Gastric Cancer Cell Metastasis Associated Genes / 中国药房

Tao LIANG; Tiefu LIU; Zhanjun MA; Lijun SHI; Yinhua TANG.

China Pharmacy ; (12)2001.

Article in Chinese | WPRIM | ID: wpr-518308

ABSTRACT

OBJECTIVE:

To detect the expressions of five gastric cancer cell metastasis associated genes induced by arsenic trioxide

The expressions of CD44,P53,nm23,H-ras,PCNA induced by arsenic trioxide were examined by immunohistochemistry method

Arsenic trioxide induced the decrease of the expressions of CD44,P53,PCNA in gastric cancer cells;the expressions of nm23 and H-ras were not changed by As2 O 3

It is tentatively proved that the antineoplastic action of As2 O 3 may be related to the down-regulation of CD44,P53 and PCNA

arsenic trioxide(As2 O 3 ); human gastric carcinoma cell; gene expression

Full text: Available Index: WPRIM (Western Pacific) Language: Chinese Journal: China Pharmacy Year: 2001 Type: Article

MEDLINE

LILACS

LIS

Fulltext

Full text: Available Index: WPRIM (Western Pacific) Language: Chinese Journal: China Pharmacy Year: 2001 Type: Article