Expression of transforming growth factor-?_1 in the chronic pancreatitis tissue: Pathogenesis of chronic pancreatitis / 中国普通外科杂志
Chinese Journal of General Surgery
;
(12)2001.
Article
in Chinese
| WPRIM
| ID: wpr-519865
ABSTRACT
Objective To study the effect and significance of transforming growth factor-?_1(TGF-?_1), and TGF-?_1mRNA in the pathogenesis of chronic pancreatitis. Methods The expression and distribution of TGF-?_1, and TGF-?_1mRNA in the pancreatic tissue in different stage of the pathogenesis of chronic pancreatitis were studied with immunohistochemical SP staining, in situ hybridization,and reverse transcription-polymerase chain reaction on the canine model of chronic pancreatitis . Results The Expression of TGF-?_1 and TGF-?_1mRNA were found in fibrotic tissues, fibroblasts, macrophages and endothelial cells of blood vessels.The expression of TGF-?_1 and TGF-?_1mRNA were high and lasting in the pathogenesis of chronic pancreatitis. Conclusions High expression of TGF-?_1 is closely related to the fibroblast proliferating activity, extracellular matrix overdeposition and proceeding fibrosis of pancreas.
Full text:
Available
Index:
WPRIM (Western Pacific)
Type of study:
Etiology study
/
Prognostic study
Language:
Chinese
Journal:
Chinese Journal of General Surgery
Year:
2001
Type:
Article
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