Experimental Studies on Ulinastatin in the Treatment of Ulcerative Colitis / 中国医师杂志
Journal of Chinese Physician
; (12)2001.
Article
in Zh
| WPRIM
| ID: wpr-520449
Responsible library:
WPRO
ABSTRACT
Objective To investigate the therapeautic effects of ulinastatin on ulcerative colitis(UC) and it's possible mechanism.Methods Forty adult Wistar rats were randomly divided into four groups;normal group(group A),UC group(group B),SASP(salicylazosulfapyridine) therapeautic therapeutic group(group C),ulinastatin(UTI) therapeautic group(group D). UC models were induced by trinitrophenylmethylnitramine(TNBS), Group A and Group B received 0 9% saline solution instead of ulinastatin and SASP as a control.Serum level of tumor necrotic factor-?(TNF-?),malondialdehyde(MDA),superoxide dismutase(SOD) and pathological change were measured respectively after drugs treatment for two weeks.Results Both UTI and SASP decreased the level of serum TNF-?,MDA ,increased the level of serum SOD ,and relieved mucosa lesion and pathological change in UC rats . UTI was better than SASP in the treatment of UC.Conclusions UTI has apparent therapeautic effects.The mechanism may be associated with inhibition of pro-inflammatory cytokines and clearance of free radicals.
Full text:
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Index:
WPRIM
Type of study:
Prognostic_studies
Language:
Zh
Journal:
Journal of Chinese Physician
Year:
2001
Type:
Article