The angiogenesis effect of intermittent hypoxia precondition on ische micmyocardium in rabbits / 中国病理生理杂志
Chinese Journal of Pathophysiology
;
(12)1986.
Article
in Chinese
| WPRIM
| ID: wpr-521936
ABSTRACT
AIM:
To determine the effect of intermittent hypoxia (IH) precondition on ischemic myocardium by using a rabbit model of chro nic myocardial ischemia with left anterior descending (LAD) banding.METHODS:
Male, adult New Zealand white rabbits were assigned into three groups randomly. (1) normal group (N group), (2) control group (C group), (3) IH precondition group (H group). A LAD band was placed in C and H group firs t. The rabbits in H group were exposed to altitude of 5 000 m, for 6 h/day c ontin uously. According to IH precondition duration, the animals were subdivided into 7-days group (H1) and 42-days group (H2). After these experiments, the mRNA conc entrations of vascular endothelial growth factor (VEGF), hypoxia induced factor (HIF-1?), endothelial nitric oxide synthase (eNOS) and the expression of VEGF p rotein were detected. Tissue sections were stained for alkaline phosphatase with indoxyl-tetrazolium method to detect capillary density.RESULTS:
The mRNA levels of VEGF, HIF-1?, eNOS and expression V E GF protein were increased in H group significantly. Compared with C and N group, the capillary density in H group was increased significantly.CONCLUSION:
IH precondition increases angiogenesis in chronic is chemic myocardium in rabbits.
Full text:
Available
Index:
WPRIM (Western Pacific)
Type of study:
Prognostic study
Language:
Chinese
Journal:
Chinese Journal of Pathophysiology
Year:
1986
Type:
Article
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