CCR7~+CD8~+CD45RO~+ T Cells induced Differentiation of CD4~+T Cells to Th2 Cells in Active Systemic Lupus Erythematosus / 中华皮肤科杂志
Chinese Journal of Dermatology
; (12)1994.
Article
in Zh
| WPRIM
| ID: wpr-524943
Responsible library:
WPRO
ABSTRACT
Objective To determine the functions of CCR7+CD8+CD45RO+ T cells on CD4+T cells in systemic lupus erythematosu(SLE).Methods The expres sion of cytokines in CD4+T cells was measured by flow cytometry,real-time qua ntitative reverse transcription polymerase chain reaction and Northern blotting.A chemotaxis assay was used to detect their functions.Results In the case of active SLE,CCR7+CD8+CD45RO+T cells could induce CD4+T cells to express high le vels of Th2-cytokine (IL-4),and low levels of Tr1-cytokines (IL-10 and TGF-?),than those in normal controls and inactive SLE (P
Full text:
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Index:
WPRIM
Language:
Zh
Journal:
Chinese Journal of Dermatology
Year:
1994
Type:
Article