Responsibility of auditory event-related potential in rats / 中国耳鼻咽喉头颈外科

ABSTRACT

OBJECTIVE To explore whether auditory event-related potential (AERP)exists in rat and what its features are,and to set up a set of AERP recording technique. METHODS Ten normal juvenile and 10 adult rats were served as subjects. Each rat was anesthetized and recorded AERP with passive mode. The responsibility of AERPs between juvenile and adult rats was compared. Also,the responsibility of AERP between rats and normal humans was compared. RESULTS AERPs could be evoked with passive recording mode in rats. Although the latencies and amplitudes of juvenile rats were respectively shorter and lower than thoses of adult rats,there were no significance in statistics. The AERP waveform of rats was similar to that of humans essentially. However,compared to the humans,the responsibility and stability of AERP in rats were less satisfied. CONCLUSION A similar AERP exists in rat and human. AERP has a process of development,differentiation and maturation,which may accomplish in early age in rat. Rat can serve as the candidate animal for AERP research.