Preventive effects of curcumin on status epilepticus induced by lithium chloride-pilocarpine / 中国医师杂志
Journal of Chinese Physician
; (12)2001.
Article
in Zh
| WPRIM
| ID: wpr-528359
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WPRO
ABSTRACT
Objective To investigate the preventive effects of curcumin for status epilepticus(SE) induced by lithium chloride-pilocarpine.Methods Totally 45 Sprague-Dawley(SD) rats were randomly divided into three groups: preventive group(n=15),non-preventive group(n=15),and control group(n=15).The latency peroid and incidence of SE were recorded.The surviving neurons were stained by using nissl staining,and the programme death cells were detected by using terminal deoxynucleotidyl transferase-mediated dUTP nick end labeling(TUNEL) in hippocampal CA3.Results The SE incidence of preventive group was 66.7%,which was significantly lower than that of non-preventive group(P0.05).Conclusion Pretreatment of curcumin can prevent the SE induced by lithium chloride-pilocarpine and the pretreatment can not protect the neuron.
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WPRIM
Language:
Zh
Journal:
Journal of Chinese Physician
Year:
2001
Type:
Article