Absorption Kinetics of Simvastatin in Rats / 中国药房
China Pharmacy
; (12)2005.
Article
in Zh
| WPRIM
| ID: wpr-530792
Responsible library:
WPRO
ABSTRACT
0.025 63 h-1).A linear relation between absorption and concentration was noted for simvastatin at a concentration of 1.0~20.0 ?g?mL-1;and within a pH value of 5.0~7.4,the absorption of simvastatin was not affected.CONCLUSION:Simvastatin showed absorption behavior in the whole section of intestine.The absorption of the drug conforms to the passive transport mechanism and first-order kinetics.The results indicate that simvastatin can be formulated and prepared into sustained-release drug delivery system.
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WPRIM
Language:
Zh
Journal:
China Pharmacy
Year:
2005
Type:
Article