Pravastatin vs. Simvastatin in Lipid-regulating Efficacy and Safety / 中国药房
China Pharmacy
; (12)1991.
Article
in Zh
| WPRIM
| ID: wpr-531861
Responsible library:
WPRO
ABSTRACT
OBJECTIVE:
To evaluate the efficacy and safety of Pravastatin versus Simvastatin in downregulating low density lipoprotein cholesterol(LDL-C) and upregulating high density lipoprotein cholesterol(HDL-C).METHODS:
A total of 66 patients with hypercholesterolemia were enrolled 33 were randomly assigned to receive Pravastatin(40 mg) for 6 weeks,and another 33 to receive Simvastatin(40 mg) for 6 weeks.Serum lipid levels at baseline and 6 weeks after medication were measured.The primary effective indicator was LDL-C as compared with baseline value and the secondary effective indicator was HDL-C.Safety was evaluated based on laboratory data and clinical adverse reactions.RESULTS:
Both Pravastatin and Simvastatin significantly decreased LDL-C level,showing significant differences as compared with before medication(P0.05).Less adverse drug reactions were noted in both groups.CONCLUSION:
Pravastatin and Simvastatin were equivalent in lipid-regulatory effect and both were well-tolerated.
Full text:
1
Index:
WPRIM
Language:
Zh
Journal:
China Pharmacy
Year:
1991
Type:
Article