Study of the Antagonist Effects of Sodium Salicylate on the Cisplatin Induced Hearing Impairment in Guinea Pigs / 听力学及言语疾病杂志
Journal of Audiology and Speech Pathology
; (6)1998.
Article
in Zh
| WPRIM
| ID: wpr-531975
Responsible library:
WPRO
ABSTRACT
Objective To investigate the antagonist effects of sodium salicylate(NaSA) on the cisplatin(CDDP) induced hearing impairment in guinea pigs.Methods 60 guinea pigs were randomly divided into four groups ①CDDP +NaSA(50 mg/kg) group,②CDDP +NaSA(100 mg/kg) group,③CDDP +NaSA(150 mg/kg) group and ④CDDP +NS(normal saline) control group.Auditory brainstem response(ABR) and distortion product otoacoustic emission(DPOAE) were used to evaluate their effects on hearing threshold and DPOAE amplitudes.Results The ABR responses of groupsⅠ,Ⅱ and Ⅲ were significantly lower than in the control group(P0.05).The ABR responses for group Ⅰ were significantly higher than group Ⅲ(P
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WPRIM
Language:
Zh
Journal:
Journal of Audiology and Speech Pathology
Year:
1998
Type:
Article