Dietary soy isoflavones decrease methylglyoxal formation and prevent the diabetic cataracts in streptozotocin-induced severe diabetic rats / 中国病理生理杂志

ABSTRACT

AIM:Methylglyoxal (MG) is considered as a very active free radical,which is an important contributor to diabetic complications such as cataracts. The purpose of this study was to investigate the serum MG levels and protective effects of soybean isoflavones on streptozotocin induced diabetes. METHODS:Diabetes was induced in male Sprague -Dawley rats by intraperitoneal injection of 100 mg/kg streptozotocin (STZ). Diabetic rats were then randomly di-vided into 3 groups and received a special diet supplemented with casein (diabetes),low -isoflavone soy protein (diabetes + LIS),or high-isoflavone soy protein (diabetes + HIS) for 8 weeks,respectively. RESULTS:Compared to the diabetes or diabetes + LIS groups,diabetes + HIS diet significantly increased serum insulin levels,and reduced serum glucose,HbA1c and methylglyoxal levels (P